: the middle of the three primary germ layers of an embryo that is the source of many bodily tissues and structures (such as bone, muscle, connective tissue, and dermis)
broadly : tissue derived from this germ layer

Word History

Etymology

International Scientific Vocabulary

First Known Use

1873, in the meaning defined above

Time Traveler
The first known use of mesoderm was in 1873

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Cite this Entry

“Mesoderm.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/mesoderm. Accessed 23 Apr. 2025.

Kids Definition

: the middle layer of cells of an embryonic animal from which most of the muscular, skeletal, and connective tissues develop
also : tissue derived from this layer
mesodermal adjective

Medical Definition

: the middle of the three primary germ layers of an embryo that is the source especially of bone, muscle, connective tissue, and dermis
broadly : tissue derived from this germ layer

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