tachyphylaxis
noun
                                                                                                                            
                                                            tachy·phy·lax·is
                    
                                                                                                              
                                                                                                                                  ˌtak-i-fi-ˈlak-səs  
                                                      
                                                          
            
            
               plural tachyphylaxes
                                        -ˌsēz  
    
            
        
    
                                
              
          
                                                      : diminished response to later increments in a sequence of applications of a physiologically active substance (as the diminished pressor response that follows repeated injections of renin)                                      
                
                    
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  Merriam-Webster unabridged




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