diphenhydramine
noun
di·phen·hy·dra·mine
ˌdī-ˌfen-ˈhī-drə-ˌmēn 
: an antihistamine C17H21NO used especially in the form of its hydrochloride
Examples of diphenhydramine in a Sentence
Recent Examples on the Web
By contrast, drowsy formulas containing diphenhydramine don’t interact with caffeine in this way.
—
Khloe Quill, FOXNews.com, 5 Oct. 2025
When emailed for comment, the Consumer Healthcare Products Association (CHPA), the trade association for over-the-counter medications, shared a statement in favor of keeping medications with diphenhydramine available to consumers.
—Emily Kay Votruba, EverydayHealth.com, 13 Aug. 2025
According to the review, diphenhydramine (the active ingredient in Benadryl) was approved by the Food and Drug Administration (FDA) in 1946, well before today’s more rigorous drug testing standards.
—Stephanie Brown, Verywell Health, 11 Aug. 2025
The American Pharmacists Association says patients should use caution with combination cough and cold products that contain diphenhydramine.
—Asuka Koda, CNN Money, 1 Aug. 2025
See All Example Sentences for diphenhydramine
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Khloe Quill, FOXNews.com, 5 Oct. 2025
When emailed for comment, the Consumer Healthcare Products Association (CHPA), the trade association for over-the-counter medications, shared a statement in favor of keeping medications with diphenhydramine available to consumers.
—Emily Kay Votruba, EverydayHealth.com, 13 Aug. 2025
According to the review, diphenhydramine (the active ingredient in Benadryl) was approved by the Food and Drug Administration (FDA) in 1946, well before today’s more rigorous drug testing standards.
—Stephanie Brown, Verywell Health, 11 Aug. 2025
The American Pharmacists Association says patients should use caution with combination cough and cold products that contain diphenhydramine.
—Asuka Koda, CNN Money, 1 Aug. 2025
See All Example Sentences for diphenhydramine
Cite this Entry
“Diphenhydramine.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/diphenhydramine. Accessed 29 Oct. 2025.
Copy CitationMedical Definition
diphenhydramine
noun
di·phen·hy·dra·mine
ˌdī-ˌfen-ˈhī-drə-ˌmēn
: an antihistamine used especially in the form of its hydrochloride C17H21NO·HCl to treat allergy symptoms and motion sickness and to induce sleep see benadryl
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