cilastatin
noun
ci·la·stat·in
ˌsī-lə-ˈsta-tᵊn 
variants
also cilastatin sodium
: a drug C16H25N2O5SNa that is administered intravenously in combination with the antibiotic imipenem in order to increase its effectiveness by inhibiting enzymatic breakdown in the kidney
Five days before admission, the patient was evaluated by an infectious-disease specialist and readmitted to the other hospital for intravenous administration of a three-day course of imipenem–cilastatin …—
Stephen I. Pelton et al., The New England Journal of Medicine
Stephen I. Pelton et al., The New England Journal of MedicineInclusion of cilastatin makes it possible to use imipenem against urinary tract infections.—Chemical & Engineering News
Chemical & Engineering NewsCite this Entry
“Cilastatin.” Merriam-Webster.com Medical Dictionary, Merriam-Webster, https://www.merriam-webster.com/medical/cilastatin. Accessed 31 Oct. 2025.
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