antigen

noun

an·​ti·​gen ˈan-ti-jən How to pronounce antigen (audio)
-ˌjen
: any substance (such as an immunogen or a hapten) foreign to the body that evokes an immune response either alone or after forming a complex with a larger molecule (such as a protein) and that is capable of binding with a product (such as an antibody or T cell) of the immune response
antigenic adjective
antigenically adverb
antigenicity noun

Did you know?

An antibody is a protein produced by your immune system to fight outside invaders. Since the enemy substance actually triggers the production of antibodies, such substances are called antigens—anti- being short for antibody, and -gen meaning "producer". (In a similar way, an allergen produces an allergy, and a pathogen produces a pathology or disease.) Antigens are often rodlike structures that stick out from the surface of an invading organism—usually a bacterium or a virus—and allow it to attach itself to cells in the invaded body. But unfortunately for them, in doing so they let the immune system know they're present, and the body is flooded with an army of Pac-Man-like antibodies.

Examples of antigen in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
After being exposed to a new antigen, such as during an experimental immunization, the nurse shark’s pancreas actually began producing targeted antibodies, specific to that antigen. Melissa Cristina Márquez, Forbes.com, 11 July 2025 For men, a prostate specific antigen test is done and for women a pap smear. Nicole Villalpando, Austin American Statesman, 2 July 2025 Every routine childhood vaccine antigen appears in at least one such study. Jake Scott, The Conversation, 26 June 2025 Kids today are exposed to fewer antigens — immune-revving components — than their grandparents despite getting more doses, because of improved vaccine technology, said Dr. Paul Offit, a vaccine expert at Children’s Hospital of Philadelphia. Lauran Neergaard, Chicago Tribune, 25 June 2025 See All Example Sentences for antigen

Word History

Etymology

German, from French antigène, from anticorps antibody + -gène -gen

First Known Use

1908, in the meaning defined above

Time Traveler
The first known use of antigen was in 1908

Browse Nearby Words

Cite this Entry

“Antigen.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antigen. Accessed 19 Jul. 2025.

Kids Definition

antigen

noun
an·​ti·​gen ˈant-i-jən How to pronounce antigen (audio)
-ˌjen
: a substance (as a protein) that causes the body to form antibodies against it when it is introduced into the body either alone or as part of a microscopic plant or animal
antigenic adjective

Medical Definition

antigen

noun
an·​ti·​gen ˈant-i-jən How to pronounce antigen (audio)
: any substance (as an immunogen or a hapten) foreign to the body that evokes an immune response either alone or after forming a complex with a larger molecule (as a protein) and that is capable of binding with a product (as an antibody or T cell) of the immune response
antigenic adjective
antigenically adverb

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